All prescription weight-loss drugs approved for long-term use produce significant weight loss compared with placebo. In addition, studies show that the addition of weight-loss medication to lifestyle changes results in greater weight loss than lifestyle changes alone produce.
Over the course of 12 months, that can mean a weight loss of 3 to 7 percent of total body weight beyond that achieved with lifestyle changes alone. That may seem like a modest amount, but sustained weight loss of 5 to 10 percent of total body weight can have health benefits, such as lowering blood pressure, blood sugar and triglyceride levels. https://www.mayoclinic.org/healthy-lifestyle/weight-loss/in-depth/weight-loss-drugs/art-20044832
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